Drug-Induced Diseases: Prevention, Detection, and Management, 3rd Edition

ISBN: 9781585285303
ISBN-10: 1585285307
Copyright: 2018
Edition: 3rd
Editor: Tisdale, James E., Miller, Douglas A.,
Doody's Expert Review    Score: 66
Reviewer: Patrick McDonnell,  PharmD  (Temple University School of Pharmacy)
This is the third edition of a book on how drugs can cause or contribute to organ-specific diseases. I use the term "organ specific" because the chapters mirror typical pathophysiology books by listing the drug induced illness by organ systems.
The purpose is to make healthcare providers aware that drugs can be a very common cause of iatrogenic illness and should always be part of the differential in diagnosing disease. If the drug is not the sole cause, it can certainly be contributory. This is a very important objective. As a professor of clinical pharmacy who teaches classes on this material, I know these illnesses are more commonly indicated than healthcare professionals would like to admit. In addition to listing the drugs, the authors try to identify how to detect that the drug is involved, usually establishing some sort of temporal relationship, but also more importantly identifying at-risk patients and therefore employing strategies to prevent or allay the risks.
The book is designed primarily for pharmacists and pharmacy students, but this topic and book should also be introduced or emphasized more to physicians and medical students to help them recognize how iatrogenic drug-induced disease is more common than one might want to believe.
As with any multiauthored book, there can be variation in the material covered or the quality of the text/details, although there seems to be a common template for most chapters, which list the drug-induced disease in an organ-system fashion. Chapters discuss causative agents, at-risk patients, mechanisms, and preventive strategies. In some chapters there is minimal detail on the mechanisms of how drugs cause the disease. Almost all chapters have tables that list the agents, and these can voluminous, but the details of causation are lacking in a lot of cases. The book lacks quality illustrations, which are critical for chapters focusing on drug-induced skin disorders, and for some other chapters where truly a picture is worth a thousand words. Also unusual is that the chapters, on average, have fewer than 20 pages (of rather larger font text), yet sometimes have hundreds of references (one chapter had over 700 references, while others had 30 to 40). The five introductory chapters that focus on the scope of drug-induced disease in general, drug regulatory practices, epidemiology of drug induced disease, post-marketing surveillance, and evaluating patients to include drugs as part of the differential diagnosis are done well. The biggest shortcoming is the lack of detail on the mechanisms of how drugs can cause disease and some inconsistencies due to the multiple authors.
Chapters on drug-induced disease are often incorporated in general pathophysiology and drug therapeutic books and focus on some of the "big organ systems" i.e., drug-induced hepatotoxicity, drug allergy, etc., but this book differentiates the topics much more, and is somewhat unique in that approach. .
Review Questionnaire
Range Question Score
1-10 Are the author's objectives met? 8
1-10 Rate the worthiness of those objectives. 8
1-5 Is this written at an appropriate level? 1
1-5 Is there significant duplication? (1=significant, 5=insignificant) 4
1-5 Are there significant omissions? (1=significant, 5=insignificant) 3
1-5 Rate the authority of the authors. 3
1-5 Are there sufficient illustrations? 3
1-5 Rate the pedagogic value of the illustrations. 3
1-5 Rate the print quality of the illustrations. 2
1-5 Are there sufficient references? 1
1-5 Rate the currency of the references. 4
1-5 Rate the pertinence of the references. 4
1-5 Rate the helpfulness of the index. 3
1-5 If important in this specialty, rate the physical appearance of the book 3
1-10 Is this a worthwhile contribution to the field? 6
1-10 If this is a 2nd or later edition, is this new edition needed? 10