Concepts in Pharmacogenomics: Fundamentals and Therapeutic Applications in Personalized Medicine, 2nd Edition

ISBN: 9781585285167
ISBN-10: 1585285161
Copyright: 2017
Edition: 2nd
Editor: Zdanowicz, Martin M.
Doody's Expert Review    Score: 89
Reviewer: Patrick McDonnell,  PharmD  (Temple University School of Pharmacy)
This user-friendly book presents the fundamentals of pharmacogenomics and discusses how to correctly and optimally apply pharmacogenomics to patient-specific dosing. The first edition was published in 2010.
The purpose is to highlight the basic concepts of pharmacogenomics and their application to optimize therapy, avoid therapeutic failure, or prevent adverse drug reactions. In the preface the editor highlights President Obama's reference to precision medicine in his 2016 State of the Union Address, clearly to show how personalized medicine is becoming a key area of research and a key area for the future of medicine.
As a pharmacy educator, when I saw the term pharmacogenomics, I thought this would be an obvious book for pharmacists and pharmacy students. However, it's written at a level that one does not need to be a PhD geneticist to appreciate. It would be an excellent reference for a wide array of healthcare practitioners, including physicians, nurses, physician assistants, nurse practitioners, and students of these disciplines. The editor has been a healthcare educator and administrator for years, and has a special research interest in pharmacogenomics. Contributing authors are mainly academicians from the field of pharmacy.
The book is divided into three parts. The first part has several chapters on the fundamentals of pharmacogenomics. The level of presentation makes it an appropriate memory jog for those who had some exposure to genetics in college biology, and an introduction to the basics with key fundamentals reinforced by case applications and boxed clinical pearl highlights for those with little to no previous exposure. Part II then focuses on the applications of pharmacogenomics in therapeutics, and the chapters are divided by organ-specific disease states (i.e., cardiovascular disease, oncology), along with chapters about toxicogenomics (specific adverse reactions associated with pharmacogenomic variants), and the pharmacogenetics of addiction. Part III has several general chapters on other important issues such as ethics and pharmacogenomics, drug labeling and testing availability, the role of pharmacists in pharmacogenomics, and the future of this discipline.
I recently completed an eight-week course in pharmacogenomics for my own continuing education and interest, so it was apropos that this book came to me for review. The book is thorough in presenting the fundamentals of the science without being overwhelming, and the application sections are very practical and user friendly. I recall the first edition of this book, so it's nice to see the updates in this ever changing and exciting field. I could certainly see this being used as a textbook in pharmacy schools, as well as a user-friendly resource for those desiring information on this topic.
Review Questionnaire
Range Question Score
1-10 Are the author's objectives met? 10
1-10 Rate the worthiness of those objectives. 10
1-5 Is this written at an appropriate level? 5
1-5 Is there significant duplication? (1=significant, 5=insignificant) 5
1-5 Are there significant omissions? (1=significant, 5=insignificant) 4
1-5 Rate the authority of the authors. 4
1-5 Are there sufficient illustrations? 5
1-5 Rate the pedagogic value of the illustrations. 4
1-5 Rate the print quality of the illustrations. 4
1-5 Are there sufficient references? 5
1-5 Rate the currency of the references. 4
1-5 Rate the pertinence of the references. 4
1-5 Rate the helpfulness of the index. 5
1-5 If important in this specialty, rate the physical appearance of the book 4
1-10 Is this a worthwhile contribution to the field? 8
1-10 If this is a 2nd or later edition, is this new edition needed? 8